Endocrine Abstracts

Introduction: NAFLD has become the leading cause of liver disease in the Western world and has a strong association with obesity and diabetes. There are no studies of NAFLD in pregnant women.Methods: Pregnant volunteers (n=57) were recruited in the first or third trimester and evaluated for the presence of NAFLD using abdominal ultrasound scans using accepted criteria. Liver biopsies were not performed since this invasive procedure would present u...

Prolactinomas are the commonest type of functioning pituitary adenoma in man. High circulating oestrogen levels are associated with lactotroph proliferation and increased PRL secretion essential for lactation. In vitro, oestradiol induces proliferation of the rat pituitary somatolactotroph GH3 cell line, and chronic oestrogen treatment of Fischer-344 rats in vivo results in lactotroph hyperplasia and adenoma formation, though the mechanisms responsible remain elu...